This work benefits from State aid managed by the National Research Agency under the investment program for the Future integrated to France 2030 bearing the reference ANR-18-RHUS-0008
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Located within the Lariboisière Hospital in Paris since 2020, the EviRed Reading Center was specifically designed to meet the needs of the project. It provides expert, centralized, and standardized interpretation of ophthalmic images collected as part of this prospective cohort study.
With a team of trained graders, the center processes ultra-widefield multimodal images (color fundus photography, OCT, OCT-A), using a standardized terminology to identify, analyze, and localize retinal lesions. This approach ensures traceability of assessments and the creation of a high-quality annotated dataset — a key foundation for the development, training, and validation of the project’s artificial intelligence algorithms.
On a daily basis, the reading center operates with the support and involvement of our partners: Carl Zeiss Meditec, ADCIS, and Evolucare.
The EviRed Reading Center is supported by a multidisciplinary team combining advanced medical and technical expertise.
Image interpretation is conducted by retina-specialist ophthalmologists with recognized experience in multimodal imaging analysis, as well as by orthoptists and clinical research technicians specifically trained in image reading protocols within the framework of clinical trials.
This clinical team works in close collaboration with two data scientists responsible for ensuring the availability and organization of imaging data, with the support of our partners ADCIS and Evolucare.
The center’s operations are overseen by our two medical leads, Dr. Sophie BONNIN and Prof. Pascale MASSIN, who also actively contribute to the training and supervision of the grading team.
The Reading Center is responsible for interpreting various types of imaging data collected during examinations performed in the 3,086 included patients across 14 partner ophthalmology departments in France.
Imaging sessions are conducted every day for patients enrolled in the EviRed cohort. We process images acquired from a variety of devices, including wide-field color fundus photographs, OCT and OCT-Angiography from PlexElite, Cirrus, Spectralis, Optovue and Topcon systems.
To ensure the quality and reliability of our assessments, each image is independently reviewed and annotated by two separate graders. In the event of a discrepancy, the image is submitted to an experienced super-grader for arbitration.
On a monthly basis, an average of 1000 images are reviewed and annotated. Graders work in a blinded manner on anonymized images, ensuring the highest possible level of objectivity in their assessments.
Discover our activity as seen by a grader
At EviRed reading center, we leverage advanced expertise in OCT-A (Optical Coherence Tomography Angiography) to visualize the retinal microvasculature with unmatched precision. This non invasive imaging technology is central to our mission: improving the detection, monitoring, and understanding of diabetic retinopathy by combining cutting edge innovation with clinical excellence.
This work benefits from State aid managed by the National Research Agency under the investment program for the Future integrated to France 2030 bearing the reference ANR-18-RHUS-0008