Deep Learning tools for evaluation of diabetic retinopathy and maculopathy »PhD thesis defended by Dr. H. Le Boite

On April 8th, 2025, Dr. Hugo Le Boité successfully defended his PhD thesis titled “Deep Learning tools for evaluation of diabetic retinopathy and maculopathy”. This marked the culmination of a three and a half-year journey during which Dr. Le Boité developed and applied tools for the segmentation of retinal non-perfusion in OCT-Angiography images in diabetic retinopathy, tools for the segmentation of pathological fluids in OCT images, as well as innovative methodological approaches to alleviate the manual annotation burden when constructing large database of medical images in the purpose of training efficient deep learning models.

The defense was held in the presence of a jury comprising the following members:

  • Mr. Raphael Sznitman: professor and research director at the ARTORG center for biomedical engineering and research, Bern Switzerland.
  • Ms. Alexandre Miere: assistant professor of ophthalmology in the ophthalmology department of the Creteil Hospital (Centre Hospitalier Intercommunal de Créteil, France)
  • Mr. Fabrice Meriaudeau: professor, and research director at the Medical Imaging group, Université de Bourgogne. President.
  • Mr. Xavier Guillonneau: research director at the Institut de la Vision, Sorbonne Université, Paris, France.
  • Ms. Catherine Creuzot Garcher: professor, ophthalmology department of the Dijon University Hospital, France.
  • Mr. Gwenolé Quellec: research director, INSERM, LaTIM, UMR-1101.
  • Ms. Aude Couturier: professor, ophthalmology department of the Lariboisière hospital, Paris, France.

This research provides potential deep learning tools that could be applied in clinical practice for automatic segmentation of specific biomarkers, but also provides interesting methodological techniques that will be applied in future projects in order to optimize manual annotation in the production of medical image segmentations.

Appearing in the top picture, from left to right: Fabrice Meriaudeau, Hugo Le Boité, Xavier Guillonneau, Gwenolé Quellec, Aude Couturier, Alexandra Miere. Catherine Creuzot Garcher and Raphael Sznitman participated remotely.

The Evired Team at « Retine en Pratique » in Paris on the 28th March 2025

Part of the Evired Team met during the 20th edition of the « Rétine en Pratique » congress organized in Paris on the 28th of March and led by Pr Aude Couturier and Pr Alain Gaudric.

The congress was dedicated to all secrets of the choroid and we learned a lot!

It is always a pleasure to exchange all together on Retina topic.

Members of the clinical sites (principal investigators, investigators, orthoptists, study coordinators…) and reading center graders were present.

Although the congress had over 500 participants, only a small number of us were available to be present for the photo.

The EviRed adventure continues, so stay tuned!

Celebrate the 5th anniversary of EviRed! 🎉

Today, we are delighted to celebrate an important milestone in our journey: the fifth anniversary of our project!

Over the past five years, we have had the honor to work on this innovative project promoted by AP-HP and supported by ANR and we would like to share our achievements and their impact :

  • More than 3000 patients are enrolled in the clinical study in the 14 French sites. Their longitudinal data collected (contextual data and images) are key for the project. Deep Thanks to the patients for their contribution… And we are happy to announce that the follow up will continue this year !

We want to express our gratitude to all the stakeholders at sites for the tremendous work they accomplish daily: investigators, co-investigators, orthoptistes and study coordinators that follow the daily work on site.

A big shout also to the URC team improving the   data set quality with their data cleaning activities.

  • Our industrial partners Evolucare, Adcis and ZEISS worked hand-in -hands with AP-HP to enable the review of all the patient collected images  at the reading center based in Lariboisière hospital AP-HP.

Thanks to IT Teams and partners to permit the set of the reading center and to the graders and supergraders. The reading center already reviewed more than 15 000 images!

  • Our dedicated Ai teams have already published several articles on various innovative approachs for the developement of algorithms wich could ultimately  serve unmet needs in Diabetic Retinopathy.Thanks to LaTim teams.

 

This year is particularly special, as it marks the last step before finalizing our algorithm. We look forward to sharing with you the advances that will transform the life of patients and impact the daily lives of ophthalmologists to choose the best strategy on the monitoring of the Diabetic Retinopathy

Thank you to all who have been with us throughout this journey. Your support is invaluable and we look forward to continuing this adventure together!

🎈 Let’s stay connected and celebrate together! 🎈

Longitudinal and Multi-Modal Monitoring for Diabetic Retinopathy Detection Using Deep Learning” thesis Defense by Rachid Zeghlache

On December 12, 2024, Dr. Rachid Zeghlache successfully defended his PhD thesis titled “Longitudinal and Multi-Modal Monitoring for Diabetic Retinopathy Detection Using Deep Learning”. This marked the culmination of a three-year journey during which Dr. Zeghlache explored various innovative approaches to tackle a central challenge of the Evired project: predicting the future progression of diabetic retinopathy in patients based on imaging and contextual data.

The defense was held in the presence of a jury comprising the following members:

  • Mr. François ROUSSEAU: Professor, IMT Atlantique, president
  • Ms. Alice OTHMANI: Associate Professor (HDR), LISSI, Université Paris-Est Créteil (UPEC), reviewer
  • Ms. Marie BEURTON-AIMAR: Associate Professor (HDR), LaBRI, Université Bordeaux, reviewer
  • Mr. Gwenolé Quellec: Research Director, INSERM, LaTIM, UMR-1101
  • Mr. Mathieu LAMARD: Research Engineer (HDR), LaTIM, UMR-1101, director
  • Mr. Pierre-Henri CONZE: Associate Professor (HDR), IMT Atlantique
  • Mr. Mostafa EL HABIB DAHO: Researcher (CPJ), UBO – HDR, LaTIM, UMR-1101

This groundbreaking research lays the foundation for personalized, AI-driven management of diabetic retinopathy and is expected to inspire significant innovations during the final stages of the Evired project.

NB: on the picture from the left to the right: François Rousseau, Pierre-Henri Conze, Gwenolé Quellec, Dr. Rachid Zeghlache, Mathieu Lamard, Alice Othmani, Mostafa El Habib Daho (Marie Beurton-Aimar participated remotely).

The Evired team was present at the “Retina and Diabete” organized by Pascale Massin and Catherine Creuzot Garcher

The 4th « Retine and Diabete » congress has been hold in Paris last Friday November 29th

The whole day focused on latest developments as well future of Diabetis and its impact on the eye with interactive and valuable discussions between diabetologists and ophthalmologists.

 

This has also been the opportunity for Evired stakeholders to meet and exchange : investigators, dedicated TEC teams and orthoptists from APHP and Broca center, reading center team and some of the consortium partners (Latim and Evolucare) were excited to note the key relevance of our project for patients with DR.

 

On the pictures (from top to bottom and from left to right) : L. EL AYADI, S. EL FADILI, D. BOUHASSANE, Dr P. GASCON, Pr C. CREUZOT-GARCHER, M. EL HABIB DAHO, A. ZUREIK, Pr JF KOROBELNIK, N. HAMOUDI, Z. HAMAINI , E. GAIDUR, C. LEPICARD, Pr P. MASSIN, Pr A. COUTURIER, Dr S. BONNIN, Dr N. BATAILLE, Dr L.BEC, Dr A. COLETTO, Dr M.EL BARKANI

MICCAI 2024 – Presence of EviRed team and IA challenges lead by LaTIM team

As in previous years, LaTIM members represented the EVIRED consortium at MICCAI, the premier conference on AI for medical image analysis.

  • Rachid Zeghlache presented his latest work on longitudinal retinal image analysis and chaired an engaging oral session on the MARIO challenge, focused on the longitudinal analysis of retinal OCT images, and organized by EVIRED.
  • At the same time, Gwenolé Quellec chaired another oral session on the DIAMOND challenge, which focused on predicting the onset of diabetic macular edema using ultrawide-field fundus photography. This session, also organized by EVIRED and sponsored by Zeiss, was supported remotely by Mostafa El Habib Daho.

Both challenge events provided excellent opportunities to promote the EVIRED project within the medical AI community. Naturally, we made sure to explore the beautiful city of Marrakesh!