On the 26 April 2024, Dr Sophie Bonnin, defended her PhD thesis brilliantly entitled “Topology and morphometry of healthy and pathological human retinal capillaries “.
This presentation was very emotional and dedicated to Pr. Ramin Tadayoni who passed away few days before, and who have always supported and encouraged us to achieve high goals.
This was the achievement of a long journey of more than 3 years of hard work, under the direction of Professor Aude Couturier (Lariboisière Hospital) and Professor Michel Paques (Hospital of XV-XX)
The defense took place in the presence of a jury composed of the following members:
- Bahram Bodaghi, Professor of Ophthalmology, Pitié Salpêtrière Hospital, Sorbonne Université, President of the jury
- Marcela Szopos, Professor in Applied Mathematics, CNRS, MAP5, Université Paris Cité,
- Marie-Noëlle Delyfer, Professor of Ophthalmology, , Centre Hospitalier Universitaire de Bordeaux ,Université de Bordeaux
- P Alain Gaudric, Professor of Ophthalmology, APHP, Hôpital Lariboisière and Université de Paris
- José-Maria Fullana, Professor in Biomechanics of fluid, department of Mechanical Engineering, Institut Jean Le Rond d’Alembert, UMR 7190, Sorbonne Université, CNRS Paris
- Xavier Guillonneau, Research Associate, Sorbonne University, INSERM, CNRS, Institut de la Vision, Paris.
The aim of this thesis was to deepen the analysis and understanding of the physiological and pathological retinal microcirculation, with a special focus on diabetes, using innovative modern clinical imaging technologies.
The first part was dedicated to the characterization of the retinal microcirculation in healthy subjects by combining several high-resolution imaging technologies, in particular optical coherence tomography angiography and ophthalmoscopy, both corrected by adaptive optics, showing the 3D organization of the capillary layers.
The second part studied the early microvascular manifestations of diseases affecting the microcirculation by evaluating patients with diabetes and patients suffering from Takayasu’s disease.
This work paves the way for a new analysis of neurovascular relationships in the human retina, which may provide a new basis for modelling blood flow in neural tissue.
This work was performed in XV-XX hospital (CIC 1423) with the excellent Paris Eye Imaging team.
This thesis has been possible with the support of RHU EviRed, Horizon 2020 research and innovation programme, Région Ile-de-France and IHU ForeSight, and the teams of XV-XX, Lariboisière Hospital Rothschild Foundation Hospital and Pitié-Salpêtrière Hospital.
For the RHU Evired, Dr. Sophie Bonnin has been involved in the project since its inception and contributes significantly to the daily work, particularly in the establishment and follow-up of the Reading Centre.
Her main interest area work are dedicated to imaging, retina and neuro-ophthalmology area.
NB: on the picture from the left to the right: Pr. Marcela Szopos, Pr. José-Maria Fullana, Pr. Bahram Bodaghi, Pr. Aude Couturier, Dr. Sophie Bonnin, Pr. Michel Paques, Dr. Xavier Guillonneau, Pr. Marie-Noëlle Delyfer .Via web connection Pr Alain Gaudric
